If all other deployment methods do not work, CGI will work for sure. CGI is supported by all major servers but usually has a less-than-optimal performance.
This is also the way you can use a Werkzeug application on Google’s AppEngine, there however the execution does happen in a CGI-like environment. The application’s performance is unaffected because of that.
First you need to create the CGI application file. Let’s call it yourapplication.cgi:
#!/usr/bin/python
from wsgiref.handlers import CGIHandler
from yourapplication import make_app
application = make_app()
CGIHandler().run(application)
If you’re running Python 2.4 you will need the wsgiref package. Python 2.5 and higher ship this as part of the standard library.
Usually there are two ways to configure the server. Either just copy the .cgi into a cgi-bin (and use mod_rerwite or something similar to rewrite the URL) or let the server point to the file directly.
In Apache for example you can put a like like this into the config:
ScriptAlias /app /path/to/the/application.cgi
For more information consult the documentation of your webserver.